ABSTRACT
Multiple endocrine neoplasia type 1 (MEN1) syndrome is characterized by combined occurrence of tumors of endocrine glands including the parathyroid, the pancreatic islet cells, and the anterior pituitary gland. Parathyroid involvement is the most common manifestation and usually the first clinical involvement inMEN1 syndrome, followed by gastroentero-pancreatic neuroendocrine tumors (NETs). Here we present a case where the patient initially presented with metastatic gastric NET and a single parathyroid adenoma was detected incidentally on â¶â¸Ga-DOTANOC PET/CT done as part of post ¹â·â·Lu-DOTATATE therapy (PRRT) follow-up. Further ¹â¸F-fluorocholine PET/CT showed four adenomas for which the patient subsequently underwent subtotal parathyroidectomy.
ABSTRACT
Multiple endocrine neoplasia type 1 (MEN1) syndrome is characterized by combined occurrence of tumors of endocrine glands including the parathyroid, the pancreatic islet cells, and the anterior pituitary gland. Parathyroid involvement is the most common manifestation and usually the first clinical involvement inMEN1 syndrome, followed by gastroentero-pancreatic neuroendocrine tumors (NETs). Here we present a case where the patient initially presented with metastatic gastric NET and a single parathyroid adenoma was detected incidentally on ⁶⁸Ga-DOTANOC PET/CT done as part of post ¹⁷⁷Lu-DOTATATE therapy (PRRT) follow-up. Further ¹⁸F-fluorocholine PET/CT showed four adenomas for which the patient subsequently underwent subtotal parathyroidectomy.
Subject(s)
Humans , Adenoma , Endocrine Glands , Follow-Up Studies , Gastrinoma , Hyperparathyroidism , Islets of Langerhans , Multiple Endocrine Neoplasia Type 1 , Neuroendocrine Tumors , Parathyroid Neoplasms , Parathyroidectomy , Pituitary Gland, Anterior , Positron Emission Tomography Computed Tomography , Receptors, Somatostatin , SomatostatinABSTRACT
Anaplastic thyroid carcinoma is an uncommon, highly aggressive malignancy usually presenting in the elderly. An eighteen year old boy was recently diagnosed as anaplastic carcinoma of the thyroid. PET/CECT scan performed for staging, revealed a large FDG avid heterogeneously enhancing thyroid mass with bilateral jugular venous thrombosis, which also showed increased FDG uptake, thus pointing toward tumor thrombus. To our knowledge, this is the first case wherein the PET/CT diagnosis of tumor thrombosis from anaplastic thyroid carcinoma was made in a young patient
ABSTRACT
We report an unusual case of a young male with cerebellar hemangioblastoma treated previously for medullary carcinoma of thyroid, whose PET/CT scans revealed a constellation of findings that suggested the rare Von Hippel Lindau syndrome. The diagnosis was clinched by confirming the findings on whole body contrast enhanced computed tomography [CECT] and contrast enhanced magnetic resonance imaging [CEMR]. The report highlights the need to carefully evaluate subtle findings on PET/CT that could be missed or misinterpreted as other diagnoses. It also adds to the existing literature of two cases with Von Hippel Lindau syndrome and medullary carcinoma of thyroid